Familial dyslipidemic hypertension (FDH), was defined as an observation of two or more siblings who both have hypertension and lipid abnormalities diagnosed before age 60.
These lipid abnormalities include HDL–cholesterol below the 10th percentile, triglycerides above the 90th percentile, or LDL cholesterol above the 90th percentile.
This syndrome occurs in about 12% of individuals with essential hypertension and in 1% to 2% of the general population. Hypertension and diabetes appear to increase coronary heart disease risk in part by causing an abnormality in lipid metabolism. Most affected are patients with FDH and noninsulin dependent diabetes mellitus.
In 16-year follow-up from the time of diagnosis of FDH, the NHLBI twin study showed that dyslipidemia and hypertension produced a coronary mortality rate four times higher than either dyslipidemia alone or hypertension alone.
Familial dyslipidemic hypertension
